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Re:Neuroleptics brain specific antihistaminergic? undopaminergic

Posted by SLS on February 13, 2023, at 21:41:38

In reply to Re:Neuroleptics brain specific antihistaminergic? Jay2112, posted by undopaminergic on February 12, 2023, at 12:00:25


I just read that the H3 receptor is exclusively a presynaptic autorececeptor. Is this your understanding as well?

If H3 receptors operate like DA and NE presynaptic autoreceptors, an agonist of H3 autoreceptors would reduce the presynaptic release of histamine. This would be analogous to the pharmacodynamics of clonidine. Clonidine is selective as an agonist of presynaptic NE alpha-2 autoreceptors. The net effect is to reduce presynaptic NE release. Depression is a very common side effects of clonidine. Mirtazepine is the antithesis of clonidine. It is a selective *antagonist* of presynaptic NE alpha-2 autoreceptors. It increases the release of NE. The net effect of mirtazepine is to act clinically as an antidepressant. However,there are other properties of mirtazepine that must be considered when explaining how it produces its antidepressant effects. I don't know much about how mirtazepine acts at postsynaptic serotonin receptors. Does mirtazepine cause a net increase in DA activity in the prefrontal cortext?

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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