Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re:Neuroleptics brain specific antihistaminergic?

Posted by undopaminergic on February 6, 2023, at 12:45:07

In reply to Re:Neuroleptics brain specific antihistaminergic?, posted by SLS on February 5, 2023, at 19:43:04

> > Next question: Do MAOI increase histamine?
> Like dopamine (DA), norepinephrine (NE), and serotonin (5-HT), the histamine molecule is a biogenic amine. Monoamine oxides type A (MAO-A) leaves histamine virtually untouched. MAO-B metabolizes (breaks-down) histamine, but to a very small degree. MAO exists *inside* the neuron, but not outside the neuron. Histamine is metabolized *outside* the neuron by an enzyme called diamine oxidase (DAO). Another enzyme located outside the neuron is catechol-O-methyltransferase (COMT). As with the MAO enzyme located inside the neuron, it metabolizes DA, NE, and 5-HT outside the neuron, but to a much smaller degree.

As the name implies, COMT breaks down catecholamines, but not serotonin.

> I don't know very much about how histamine functions in the body.

I don't know much about histamine either, but I've read it is the neurotransmitter whose activity is most correlated with wakefulness (and inversely correlated with the lack of wakefulness). This is perhaps not so surprising given the sedative effects of antihistamine drugs.





Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:undopaminergic thread:1121718