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Re:Neuroleptics brain specific antihistaminergic?

Posted by SLS on February 5, 2023, at 19:43:04

In reply to Re:Neuroleptics brain specific antihistaminergic?, posted by Lamdage22 on February 5, 2023, at 14:14:31

> Next question: Do MAOI increase histamine?

Like dopamine (DA), norepinephrine (NE), and serotonin (5-HT), the histamine molecule is a biogenic amine. Monoamine oxides type A (MAO-A) leaves histamine virtually untouched. MAO-B metabolizes (breaks-down) histamine, but to a very small degree. MAO exists *inside* the neuron, but not outside the neuron. Histamine is metabolized *outside* the neuron by an enzyme called diamine oxidase (DAO). Another enzyme located outside the neuron is catechol-O-methyltransferase (COMT). As with the MAO enzyme located inside the neuron, it metabolizes DA, NE, and 5-HT outside the neuron, but to a much smaller degree.

I don't know very much about how histamine functions in the body.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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