Posted by SLS on June 12, 2022, at 9:40:28
In reply to Re: ***More on the topic from another perspective..., posted by undopaminergic on June 12, 2022, at 7:24:21
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> > But, for people in pain, opioids are much safer than toxic NSAIDS, Cox inhibitors, which put people at very high risk for stroke and heart attack, as well as kidney failure. Canada pulled all Cox inhibitors from the market years ago. Their effectiveness is still widely debated.
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> I think you mean *selective* COX inhibitors, because all NSAIDs are COX-inhibitors -- it is their defining characteristic.
To be accurate, celecoxib (Celebrex) is a *specific* COX-2 inhibitor. The advantage of this specificity is that it does not inhibit COX-1. When COX-1 is inhibited, it no longer functions to maintain the health of the gastric (stomach) lining. Inhibition of COX-2 also reduces platelet aggregation. The consequences of COX-1 inhibition are ulcers and excessive bleeding.Experiments using celecoxib and rofecoxib (another specific COX-2 inhibitor that was removed from the market for cardiac concerns) showed that these two drugs were just as effective as non-specific COX-inhibiting NSAIDS. The COX-2 inhibitors just don't provoke the stomach lining to form ulcers. It also doesn't increase bleeding.
If one cannot tolerate celecoxib, a common non-specific inhibitor of both COX-1 and COX-2 can be combined with a proton pump inhibitor like omeprazole. This often allows one to take a common NSAID like ibuprofen without causing ulcers.
From what I understand, celecoxib sometimes produces gastic injury that is of greater magnitude than other NSAIDs.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.The only thing necessary for the triumph of evil is that good men do nothing.
poster:SLS
thread:1119806
URL: http://www.dr-bob.org/babble/20220530/msgs/1119886.html