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Alternatives to Olanzapine.

Posted by Schlepo on March 24, 2019, at 20:28:04

Hi. I've been on Olanzapine for almost three months (2.5mg initially, started 5mg last week) and due to some possible cognitive side effects (sluggishness, apathy, sedation, etc. - though these could also be related to depression) would really like to try something else. Other antipsychotics I've tried include Seroquel (decreased blood-pressure on a small dose) and Abilify (bad anxiety and nausea after two weeks.) I'm also on 75mg of nortriptyline (which is probably too low, but that's another story.)

I find Olanzapine to be great for anxiety, but less effective so far on depression (which just recently became severe.) Mentioned Rexulti to my pdoc, but she doesn't like prescribing "unproven" medications, and I am a bit concerned about it being too similar to Abilify.

So basically, I guess I'm looking for something that works on anxiety the same way that Olanzapine does, but pushes on depression a little bit more. I'd like to avoid dopamine agonists due to my bad reaction to Abilify, but it could be just what I need and this depression is hell. I'm also hoping for something that's easy to switch from Olanzapine, since what I'm going through is hard enough without extra withdrawal symptoms. I guess another antipsychotic would be best, but I'm open for anything. So any ideas?   


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poster:Schlepo thread:1103692
URL: http://www.dr-bob.org/babble/20190206/msgs/1103692.html