Psycho-Babble Medication | about biological treatments | Framed
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Psilocybin/Zyprexa question

Posted by meltingpot on July 26, 2018, at 11:44:59


I'm just after some advice, reassurance I guess really.

Zyprexa has been an absolute Godsend for me over the years and I've even been able to manage with just a small amount of Zyprexa daily and nothing else to get rid of my anxiety and suicidal thoughts. So you may wonder why I'm not satisfied with just this.

I suppose I'm always hoping for that elusive cure, something that will put me back to normal and fix my broken brain. Whilst I'm sooooo grateful for the medication it bothers me that underneath the medication I feel like a complete nervous wreck. At my worse, I can't sleep, I can't sit still, I just want to walk all of the time and I'm constantly fantasising about ways of killing myself. I feel empty, anxious and broken. On medication I've been able to work and study for a degree and have had some really nice times over the past 15 years. so I have been very lucky.

I was thinking about trying to get on a trial for Psilocybin. I did get on a trial two years ago but backed out at the last minute because I'm scared of the kind of trip I'm likely to have. I went to Amsterdam to try microdosing on psilocybin truffles which had zero affect on my depression.

I want to do the trial but my only concern is that psilocybin is supposed to be a 5HT2 agonist and Zyprexa is a 5HT2 antagonist. Therfore, I'm just worried that as Zyprexa helps me so much, psilocybin might have the complete opposite affect. Having said that Mirtazapine 5HT2 antagonist seemed to make my anxiety worse sometimes when I first took it. So I'm not sure if it is the 5HT2 antagonism that actually helps me.

Does anyone know why Zyprexa is such a good anxiety agent? What the mode of action is. It even helps me when I'm so anxious I'm sick and I've since read that it is used for people having Chemotherapy as it is a 5HT3 antagonist. So that explains that.





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