Posted by TriedEveryMedication on June 25, 2018, at 14:46:19
In reply to Re: Let's talk about combing SSRIs and TCAs » TriedEveryMedication, posted by ed_uk2010 on June 25, 2018, at 13:49:37
> The main issue with your fluoxetine + desipramine combination is that fluoxetine can alter the metabolism of desipramine. Cautious desipramine dose increases are therefore important to avoid the risk of unexpectedly high desipramine levels - which could lead to cardiac effects. It sounds like you've had a blood level to check this. You can also do an ECG (EKG).
>my blood levels of desipramine have been very low. my doc is kinda baffled by this because fluoxetine is supposedly such a strong 2D6 inhibitor.
poster:TriedEveryMedication
thread:1099256
URL: http://www.dr-bob.org/babble/20180521/msgs/1099299.html