Posted by linkadge on June 24, 2018, at 15:46:42
In reply to Re: Let's talk about combing SSRIs and TCAs » ed_uk2010, posted by TriedEveryMedication on June 24, 2018, at 14:39:30
I would think any risk of serotonin syndrome would present itself quickly (if it does), upon introduction or dose escalation.
Desipramine does have a metabolite which is more serotonergic. That being said, the combination of 2 reuptake inhibitors is usually safe. Like you say, desipramine mostly affects the norepineprine transporter.
Linkadge
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