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Re: More research: Celexa versus Lexapro

Posted by rjlockhart37 on May 5, 2018, at 12:56:42

In reply to More research: Celexa versus Lexapro, posted by Mtom on May 5, 2018, at 11:25:25 - "We then may conclude that R-citalopram antagonizes the antidepressive effects of escitalopram and that its presence limits the therapeutic effect and reduces the speed of action of citalopram. The antagonism of escitalopram by R-citalopram was not expected and one hypothesis is that a direct interaction between the 2 enantiomers may occur on a particular site of the serotonin transporter. Results have shown that R-citalopram has a significant affinity only for the allosteric site of the transporter, which regulates the affinity of the ligand for the active site at the origin of serotonin reuptake inhibition. Unlike citalopram, escitalopram's pharmacologic action is not blocked by R-citalopram explaining its greater therapeutic efficacy and more rapid mode of action" - "escitalopram, but not citalopram, improved recognition memory" - "Escitalopram is more powerful than citalopram in reducing anxiety but the presence of R-citalopram reduces the positive effects of escitalopram"

these sources repeatedly say that the R-citalopram counter acts escitalopram, and it said many times....."escitalopram" is more potent as an anti-depressant, the "R-citalopram" counter acts, and it has low effect on serotonin re-uptake

after reading all of these, it clearly is saying Lexapro is the better one, because it work better for anxiety and depression because the "R-citalopram" has nearly none AD activity

everything can change like that, and all these years go by so fast, but nothing lasts forever




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