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Re: How are you doing? » farshad

Posted by ed_uk2010 on April 1, 2018, at 17:40:47

In reply to Re: How are you doing?, posted by farshad on April 1, 2018, at 8:53:07

Hi Farshad,

There are a few different types of Cushing Syndrome. All types cause a large elevation of cortisol. The reason for cortisol being elevated differs between the different types.

>People with cushings have a tumor in the pituatary which releases constant cortisol and cortisol is a non peptide hormone and the effects would be very different wouldnt it? . isnt there a difference?

One cause of Cushing's is a tumour in the pituitary. It releases ACTH, not cortisol. The large amounts of ACTH cause the adrenal glands to produce large amounts of cortisol. The highly elevated cortisol levels then cause the symptoms.

>I have a tumor in the paraventricular nucleus which releases CRH and CRH is a Peptide hormone

Tumours releasing CRH are a very rare cause of Cushing Syndrome. The high CRH causes the pituitary to produce large amounts of ACTH. The ACTH causes the adrenal glands to produce large amounts of cortisol. So, the overall effect of CRH-producing tumours is Cushing Syndrome (from very high cortisol).

 

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