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Re: How do SSRIs normalise the amygdala? farshad

Posted by linkadge on February 18, 2018, at 13:01:54

In reply to Re: How do SSRIs normalise the amygdala?, posted by farshad on February 16, 2018, at 19:42:54

>the 5-ht3 is involved in anxiety?

I think it can be. 5-ht3 receptors are expressed abundantly in the GI tract. When you first take an SSRI, it can cause nausia which is believed to be due to activation of 5-ht3 receptors. Odansetron is an anti-nausia drug which blocks 5-ht3 receptors.

In the brain, they are conencted with glutamate release. Taking 5-ht3 antagonist either alone, or alongside SSRIs seems to produce / boost antidepressant effects.

5-ht3 antagonists also appear to have antianxiety effects in animal models of anxiety.

Mirtazapine is also a 5-ht3 antagonist, which is why it doesn't cause nausia, and may reduce the nausia associated with SSRIs.




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