Psycho-Babble Medication | about biological treatments | Framed
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Re: Everything is good, except for depression

Posted by SLS on November 28, 2017, at 21:28:35

In reply to Re: Everything is good, except for depression, posted by linkadge on November 28, 2017, at 19:52:01

> Hey SLS,
> desipramine seems to have a lower cardiac safety index than the other TCAs. I (personally) would be cautious about using it with lithium. I have been getting some weird cardiac effects from lithium and nortriptyline.
> Linkadge

Bundle-branch block?

When I first started taking desipramine, I experienced rapid heartbeat and palpitations. There was also a sort of "edginess" that disappeared over time. After a few weeks, palpitations disappeared completely, but rapid heartbeat only partially mitigated. I don't think there is anything wrong with having a moderately elevated heart rate, though. I've been on TCAs for over 30 years. I'll let you know after my first stress-test. My EKGs are normal. All I can say is that combining Parnate + desipramine sure packed a wallop the first time they were used together in me. My autonomic nervous system felt like it was being fried. Good stuff. I reached remission within a few months (1987). To keep a long story from becoming longer, I never responded to that treatment again.

It is a matter of risk/cost/benefit.

I hope you are doing reasonably well. It is relative, I guess. When someone asks me how I am doing, I usually answer that I could be doing worse - knowing that I could be doing a hell of a lot better.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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