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Re: Parnate and orthostatic hypotension chrismeurer

Posted by SLS on November 23, 2017, at 21:06:57

In reply to Parnate and orthostatic hypotension, posted by chrismeurer on November 23, 2017, at 12:08:12

What are the side effects of lithium that propranolol is supposed to address? Tremulousness? Is it helping?

The old way of determining therapeutic dosages of Parnate is to do an orthostatic challenge, whereby sitting blood pressure is compared to that which results immediately upon standing up. A drop of 10% is considered to be a good indicator of therapeutic levels of MAO inhibition. I don't know how taking propranolol might interfere with the interpretation of such a test. I found that dizziness is a side effect that mitigates with continued treatment. (This not necessarily true with Nardil). The presence or absence of dizziness upon standing is not a reliable index of the 10% rule.

I have come to believe strongly that with Parnate, 40-80 mg/day is the dosage range that is effective. At 30 mg/day, you might experience a temporary increase in mental energy, but I would be surprised if that dosage would end up being globally effective for you. I truly hope that you are an exception, though.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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