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Re: Wellbutrin killed libido! phidippus

Posted by SLS on October 9, 2017, at 9:37:11

In reply to Re: Wellbutrin killed libido!, posted by phidippus on October 8, 2017, at 19:52:41

> How did prazosin improve your mood?
>
> Eric

Prazosin acts like a potent antidepressant to improve all of my symptoms of depression when combined with other antidepressant drugs. This includes anergia, depressed mood, anhedonia, psychomotor retardation, cognitive slowing, memory impairments, impaired ability to read, and hyperphagia. Except for the libido issue, prazosin is remarkably clean with regard to side effects. I experienced some initial hypotension, but this wore off quickly. It is recommended that the very first dose be 1.0 mg taken at bedtime to prevent syncope. Thereafter, dosages can be taken b.i.d. or t.i.d. My doctor came up with this brilliant choice of treatment because I reported being repeatedly abused physically and emotionally beginning at a very young age. This was compounded by neglect. My doctor called this scenario "Developmental PTSD". It is now more commonly referred to as Complex Trauma Disorder or Complex PTSD. For someone who finds himself to be treatment resistant and has a history of childhood adversity, I would suggest considering combining prazosin with antidepressant drugs - especially with those that produce a partial therapeutic response.

My pet theory is that prazosin uniquely blocks brain 5-HT1b receptors to modulate dopaminergic neurotransmission.

1. Blocks presynaptic autoreceptors - increased serotonin release.
2. Blocks postsynaptic heteroreceptors - disinhibition of excitatory neurons like dopamine, glutamate, and norepinephrine.

http://www.sciencedirect.com/topics/neuroscience/5-ht1b-receptor


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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poster:SLS thread:1093568
URL: http://www.dr-bob.org/babble/20161215/msgs/1095346.html