Psycho-Babble Medication Thread 1093568

Shown: posts 1 to 11 of 11. This is the beginning of the thread.

 

Wellbutrin killed libido!

Posted by Sheilac on December 18, 2016, at 16:24:48

I'm on 150 SR Wellbutrin and my desire for sex is gone. No interest whatsoever. Totally dead. Just numb. Plus, I've become irritable and bitchy I've noticed.

I was taking 100 SR Wellbutrin and low dose Seroquel before.

I'm thinking I need to drop my dose of Wellbutrin (I'm very sensitive to meds. Could only take 5mg of Adderall).

I'd like to get my sex drive back, get rid of this increased anxiety/irritability and still get the antidepressant feel I need.

I thought Wellbutrin was supposed to boost your sex drive. A tiny dose of Adderall always did. Maybe I'm on too much Wellbutrin.

 

Re: Wellbutrin killed libido! Sheilac

Posted by SLS on December 19, 2016, at 8:25:03

In reply to Wellbutrin killed libido!, posted by Sheilac on December 18, 2016, at 16:24:48

I know this is going to sound mean, but I say it out of concern for your future:

You can't have everything.

That doesn't mean that you can't try, but I think you should accept that, for now, it will be necessary to make compromises. You have some hard decisions to make.

How badly do you want to feel well?

What are you unwilling to trade for your mental health?

For me, making the choice between losing my libido or continuing a life of pain and dysfunction was an easy one to make. So, I take 6 medications that produce side effects, one of which is a loss of libido. As important as having a libido is... Well, you get the idea.

One last comment: It may be that your libido will return once the brain accommodates to the new medication. Perhaps you should wait awhile before making any decisions.

Easier said than done.

:-(

I would remain aggressive with medication and dosages if I were in your situation. Don't lower the dosage of anything until you have an honest discussion about this with your doctor.


- Scott

 

Re: Wellbutrin killed libido!

Posted by baseball55 on December 19, 2016, at 19:11:08

In reply to Wellbutrin killed libido!, posted by Sheilac on December 18, 2016, at 16:24:48

you But didn't you just start wellbutrin very recently? It could be a start-up effect or it could be that your depression and anxiety are affecting libido. Give it a chance. I don't want to be critical, but you often freak about side-effects within days of starting something, then stop and don't give new meds a chance.

> I'm on 150 SR Wellbutrin and my desire for sex is gone. No interest whatsoever. Totally dead. Just numb. Plus, I've become irritable and bitchy I've noticed.
>
> I was taking 100 SR Wellbutrin and low dose Seroquel before.
>
> I'm thinking I need to drop my dose of Wellbutrin (I'm very sensitive to meds. Could only take 5mg of Adderall).
>
> I'd like to get my sex drive back, get rid of this increased anxiety/irritability and still get the antidepressant feel I need.
>
> I thought Wellbutrin was supposed to boost your sex drive. A tiny dose of Adderall always did. Maybe I'm on too much Wellbutrin.

 

Re: Wellbutrin killed libido! Sheilac

Posted by phidippus on October 7, 2017, at 13:40:28

In reply to Wellbutrin killed libido!, posted by Sheilac on December 18, 2016, at 16:24:48

Wellbutrin is more likely to kill your sex drive at low doses than it is at high doses. This is mainly because Wellbutrin stimulates the releas of more norepenephrine than dopamine at a low dose. Too much orepenephrine can mean lower libido.

The anxiety and irritability are not going to go away...

How many meds have you been on?

Eric

 

Re: Wellbutrin killed libido!

Posted by phidippus on October 7, 2017, at 13:43:12

In reply to Re: Wellbutrin killed libido! Sheilac, posted by SLS on December 19, 2016, at 8:25:03

Scott, I disagree. I hunted down a med regimine that did not disturb my sex drive.

And given the choice between an activity that brings great joy and pleasure and a medication that robs me of that pleasure, I'll choose joy anytime.

Eric

 

Re: Wellbutrin killed libido! phidippus

Posted by SLS on October 8, 2017, at 12:12:57

In reply to Re: Wellbutrin killed libido!, posted by phidippus on October 7, 2017, at 13:43:12

Hi Eric.

> Scott, I disagree.

What is it that you disagree with?

> I hunted down a med regimine that did not disturb my sex drive.

As have I in the past. In fact, MAOIs had increased my sex drive beyond what had been my historic normal baseline level. The increased activity that it facilitated gave me great pleasure.

> And given the choice between an activity that brings great joy and pleasure and a medication that robs me of that pleasure, I'll choose joy anytime.

You might not say that if your only source of joy is the lack of depression, regardless of how your treatment affects your libido. Unfortunately, I am currently in a position of having to choose between depression with its attendant diminished libido and a major improvement in depression with no libido at all. It's a hell of a choice to have to make, but I'll choose remission of depression anytime. Perhaps as I approach remission, I will recover some small amount of sex-drive.


- Scott


 

Re: Wellbutrin killed libido!

Posted by phidippus on October 8, 2017, at 12:20:44

In reply to Re: Wellbutrin killed libido! phidippus, posted by SLS on October 8, 2017, at 12:12:57

I recently had a bad depression (had to end it with ECT) and when I recovered from it, my libido returned. I didn't take any antidepressants.

What's this 'choice' you're facing?

Eric

 

Re: Wellbutrin killed libido! phidippus

Posted by SLS on October 8, 2017, at 19:24:06

In reply to Re: Wellbutrin killed libido!, posted by phidippus on October 8, 2017, at 12:20:44

> I recently had a bad depression (had to end it with ECT) and when I recovered from it, my libido returned. I didn't take any antidepressants.
>
> What's this 'choice' you're facing?
>
> Eric

Rightly or wrongly, I believe that my last best chance of achieving remission pharmacologically is my current treatment regime. The trajectory of improvement so far has been the best I've experienced since 1987. I consider this a miracle. I'll know better in 1-2 months whether or not the improvement continues along its current path towards remission. It might stall completely or be unable to maintain a partial improvement. So, the choice becomes whether or not to continue with my current treatment and sacrifice my sex-drive or continue life immobilized by a severe anergic depression with psychomotor retardation. Since depression all but ruins my sex-drive anyway, the decision really is an easy one to make. To be specific, it is the drug prazosin that kills my libido at all dosages. This is unfortunate as prazosin produced such a robust improvement once it was added. I spent the last two months trying to taper and discontinue the prazosin. I deteriorated, so I had to restart it. The improvement I experienced upon its reintroduction was striking. I set myself back a few months by doing this, but I think it was a worthwhile experiment.

By the way, lithium at dosages above 300 mg/day make me more depressed, not less. At 300 mg/day, lithium acts to improve the magnitude of my response to the antidepressants I currently take.

Parnate 80 mg/day
nortriptyline 100 mg/day
Lamictal 300 mg/day
lithium 300 mg/day
Abilify 15 mg/day
prazosin 20 mg/day (I'm still in the process of finding the optimum dosage of this drug)

If this treatment ultimately proves inadequate, I am thinking about discontinuing the Parnate and using either Effexor or Nardil in its place. Beyond that, I will consider brain stimulation techniques. Right now, I am interested in "deep" transcranial magnetic stimulation (dTMS) and transcranial direct current stimulation (tDCS). For now, I have ruled-out DBS. It is far too invasive, and the statistical results seem to me to be rather poor.

Thank you so much for your input. You never know from whom will come healing.

I hope all is well with you.


- Scott

 

Re: Wellbutrin killed libido!

Posted by phidippus on October 8, 2017, at 19:52:41

In reply to Re: Wellbutrin killed libido! phidippus, posted by SLS on October 8, 2017, at 19:24:06

How did prazosin improve your mood?

Eric

 

Re: Wellbutrin killed libido! phidippus

Posted by SLS on October 9, 2017, at 9:37:11

In reply to Re: Wellbutrin killed libido!, posted by phidippus on October 8, 2017, at 19:52:41

> How did prazosin improve your mood?
>
> Eric

Prazosin acts like a potent antidepressant to improve all of my symptoms of depression when combined with other antidepressant drugs. This includes anergia, depressed mood, anhedonia, psychomotor retardation, cognitive slowing, memory impairments, impaired ability to read, and hyperphagia. Except for the libido issue, prazosin is remarkably clean with regard to side effects. I experienced some initial hypotension, but this wore off quickly. It is recommended that the very first dose be 1.0 mg taken at bedtime to prevent syncope. Thereafter, dosages can be taken b.i.d. or t.i.d. My doctor came up with this brilliant choice of treatment because I reported being repeatedly abused physically and emotionally beginning at a very young age. This was compounded by neglect. My doctor called this scenario "Developmental PTSD". It is now more commonly referred to as Complex Trauma Disorder or Complex PTSD. For someone who finds himself to be treatment resistant and has a history of childhood adversity, I would suggest considering combining prazosin with antidepressant drugs - especially with those that produce a partial therapeutic response.

My pet theory is that prazosin uniquely blocks brain 5-HT1b receptors to modulate dopaminergic neurotransmission.

1. Blocks presynaptic autoreceptors - increased serotonin release.
2. Blocks postsynaptic heteroreceptors - disinhibition of excitatory neurons like dopamine, glutamate, and norepinephrine.

http://www.sciencedirect.com/topics/neuroscience/5-ht1b-receptor


- Scott

 

Re: Wellbutrin killed libido!

Posted by phidippus on October 9, 2017, at 13:16:13

In reply to Re: Wellbutrin killed libido! phidippus, posted by SLS on October 9, 2017, at 9:37:11

alpha 1-adrenoceptors stimulate dopamine release in the caudate putamen as well as in the nucleus accumbens

Maybe its effects on dopamine produce the antidepressaant qualities.

Eric


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