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Re: Studies to show doc for shorter MAOI)MAOI washout? PeterMartin

Posted by SLS on September 8, 2017, at 5:47:20

In reply to Re: Studies to show doc for shorter MAOI)MAOI washout?, posted by PeterMartin on September 8, 2017, at 2:51:59

> I hear ya but the risk of depression is a big one.
> I was on Parnate for a few months (3 I think) before switching to Marplan. Didn't washout. The doctor I had at the time was very nonchalant - perhaps to much so but I don't have any issues. Looking back my high regard for Marplan may have in part been contributed to by the Parnate jump start.
> I'll see what my doctor says tomorrow. I trust his judgement and mkst likely he'liberal' do it by the book. 14 days. Will suck.

Yes, it will suck, but it would be the safest way to go. 10 days should be okay, though.

Just remember, Marplan is in the same chemical class as Nardil (hydrazine). There is some thought (including mine) that Nardil binds to MAO more tightly than does Parnate, and that this extends the time for which monoamine neurtransmitter levels remain elevated. My guess is that Nardil is more serotonergic, and would have a greater liability to produce serotonin syndrome. I don't know if these things also apply to Marplan, but I suspect that they do.

I am not the most conservative person in the world regarding the creative application of psychotropic medication. However, going from Nardil to Parnate without a washout was a mistake. So, too, was my taking a single, very small dose of Effexor as an experiment while taking Parnate. Both of these things precipitated serotonin syndrome.

Will you be able to switch from Marplan to Nardil without a washout? Maybe. You might want to have some cyproheptadine (Periactin) handy in case you run into trouble with serotonin syndrome. I would perform an Internet search to find a list of symptoms of this reaction.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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