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Re: sedation and Parnate rjlockhart37

Posted by porkpiehat on August 5, 2017, at 11:35:57

In reply to Re: sedation and Parnate, posted by rjlockhart37 on August 5, 2017, at 0:42:32

> anti-histimine with trazadone makes an unpleasant altered mind state, hydroxyzine is an one, it's good for colds, and anxiety, but mixing those it's not pleasant, don't interact well
> but i think the tired feeling is norepinephrine and maybe a stress chemical, maybe like corisol, that strains the body, making it tired, when there stopped, it could rejuvenate back to normal....just a thought, propranolol blocks directly norepinephrine and epinephrine. I've taken metabolsim enhancers that were herbal, wierd plant stimulants.... they made me so irrtible and tired at the same time, i'm not a fan of herbal medicines, hardly work and have wierd reactions

I think we are similar. Hydroxyzine gave me very altered states the next day after I took my effexor and lamictal. Not so much now on parnate. Things like valerian root, yerba mate, ginseng, and sarcosine have always made me feel screwy. I find Lamictal often gives me this feeling depending on what else I'm taking.

I never take the hydroxyzine and trazodone at the same time.

I am juggling notions of NE action in me. Other people say it boosts their moods but both effexor and parnate and desipramine have always made my zoney, sad, and socially detatched. I can read, pack for vacation, and not lose everything I lay my hands on though.

conventional wisdom is that tiredness is caused by depleted NE, especially at initiation of MAOI. Propranolol apparent works as a NE reuptake inhibitor centrally in addition to beta blocker peripherally. So either theory could be true.




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