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Re: new to Parnate (MAOI) - Fatigue (Serotonin?)

Posted by mrSwim on December 31, 2016, at 16:13:08

In reply to Re: new to Parnate (MAOI) - Fatigue (Serotonin?), posted by pontormo on December 31, 2016, at 10:14:15

Hi pontormo,

Thanks for keeping in touch,

It's great to hear you have good success with Emsam. I would love to try it too (with an interest in L-deprenyl/selegeline, as previously mentioned).

Would you be able to tell me a little more about how it works, in terms of dose (I recall a 6mg patch is quite standard) but for example how long this patch lasts for, etc. I know orally the dose can be low at 2.5mg, or up to 5mg, 10mg, then possibly breaching into MAO-A inhibiting effects. Is the purpose of the EMSAM patch also to cross over into MAO-A inhibiting non-selective territory when it is used for depression, or is the dose sometimes maintained low enough for only MAO-B selective inhibition - even when it is used for depression?

Would love also to find out how, even if EMSAM does cross over into MAO-A inhibiting effects, how this may also be safer - being transdermal administration - than through ingesting a non-seletive MAOI... I have a vague memory that MAO-A may still be active in the GI tract when using EMSAM, as it bypasses the GI tract entirely during it's administration, thus the usual deactivation of tyramine and other amines takes place making it safer than ingested MAOI's - OR, is MAO-A still inhibited in the GI tract, even with transdermal EMSAM, once it crosses the threshold of non-selective MAO-B to MAO-A+MAO-B inhibition, regardless of transdermal administration?

Hope this all makes sense,
I'm sure I could google it all so no pressure to respond but if you'd like to share your knowledge and experiences with EMSAM I'd be very interested - thank you :)

Wishing you all the Best for the New Year ahead too :)





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