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Any luck potentiating/supplementing MAOIs?

Posted by Deahoidar on June 10, 2016, at 13:17:07

In reply to Re: MAIO's more effective than SSRI's?, posted by hoffma on May 2, 2016, at 9:47:31

> Can anyone share experience with Parnate and diet (is it really that strict) and all the meds that interact? Example if ever in an emergency, how dangerous is it to be on Parnate?

Scott (SLS)'expressed it quite well. MAOIs are usually tried only after you have had insufficient response to adequate trials of a number of meds from the other classes. This is because the other classes don't have the dietary and other cautions as MAOIs do, and they usually have lower side effect profiles.

That said, MAOIs were among the first antidepressants discovered and they can be very effective. Unfortunately, the FDA and STARD use dose ranges that are lower than what many patience need to achieve significant response.

In my experience and that of my psychiatrist, individual responses to the different MAOIs may differ. For example, Nardil caused me unacceptable side effects that did not diminish with time. Emsam had more acceptable side effects but did not help with my depression. Parnate had some side effects that diminished quickly and has helped reduce my depression when nothing else did.

Over the years, I've tried over 60 meds and augmentation combinations. This most recent episode was the worst and even DBS did help. Im finally finding some relief with 150mg Parnate, 900mg lithium, 100mg methylphenidate, 90-120mg ketamine, plus thyroxine, Mobic, ambien, sonata, Ativan, Vit. D, magnesium, etc.

MAOIs do require a patient be informed, aware, and responsible. Medication, diet and other "don'ts" are manageable. So is dental work and surgery. Just be sure you notify everyone in advance. And keep telling them, even if seems ridiculous.


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