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Re: Augmenting to Brintellix: Theory Based on a Study

Posted by Ruuudy on June 5, 2016, at 20:51:05

In reply to Augmenting to Brintellix: Theory Based on a Study, posted by LouisianaSportsman on April 14, 2014, at 22:36:26

> I read "Electrophysiological Investigations on the Role of Selected Serotonin Receptors and
> the Serotonin Transporter on Serotonin Transmission in the Rat Brain" which is a study by Maurice Lecours who works at the University of Ottawa, Institute of Mental Health Research. Rich posted this study back in March:
> First of all, Chris, you might find this excerpt "interesting", haha:
> "Clinical trials examining the use of vortioxetine for the treatment MDD have indeed demonstrated that vortioxetine separates from placebo, it is comparable to venlafaxine but with less aversive side effects, and it is effective at preventing relapse (Jain et al., 2013; Alvarez et al., 2012; Boulenger et al., 2012)."
> Hmm...
> But, what I found most interesting from the study were these following excerpts:
> "These findings indicate that either the co-administration of an SSRI in addition to a 5-HT3 receptor antagonist or a multimodal agent that acts as a SSRI and 5-HT3 receptor, such as vortioxetine, could enhance 5-HT neurotransmission to produce AD and antiemesis effects, similar to that of litoxetine, after long-term administration."
> To me it suggests that augmenting a SSRI may be a good idea because you got to keep this excerpt in mind:
> "This study has demonstrated that selective 5-HT agents alone, such as escitalopram, and multimodal agents, such as vortioxetine, alter 5-HT neurotransmission through different receptors and exert different actions, via transporter and/or receptor activity, on the serotonergic system in the hippocampus consistent with other antidepressant strategies and with a unique pharmacological profile."
> Additionally, I think you need to consider that compared to other SSRIs: "vortioxetine has a low occupancy for the 5-HTT, escitalopram was used at a dose of 5 mg/kg in order to better mimic the effects of low occupancy alone."
> I'm suggesting, based upon these excerpts from the study, Chris, that maybe you should trial whichever SSRI worked best for you in the past to augment the pharmacological effects of vortioxetine? Why not the one they used in the study? (Lexapro) Maybe the combination of the two could theoretically provide a more potent antidepressant/anxiolytic effect?
> Just a theory.

A very good theory, indeeed!

I hope that this thread will be resparked with my comment.
There's been renewed talk on Brintellix.
And I have just read these older posts about it.

I'm wondering if Brintellix might possibly be a good choice of an augmenting agent for my fluoxetine?
Would there be a risk of serotonin syndrome combining the two drugs?





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