Posted by linkadge on March 14, 2016, at 19:50:37
In reply to Re: methylation hypothesis » SLS, posted by linkadge on March 14, 2016, at 19:35:00
Here is an interesting study in which amitriptyline and valproate are shown to induce different degrees of gene demethylation (in different brain regions). Interestingly, valproate induced demethylation strongly at GLT-1 (glutamate transporter) whereas amitriptyline did not. This would be expected to result in increased activity of the glutamate transporter after valproate administration (functioning enhancing glutamate reuptake).
http://www.nature.com/npp/journal/v35/n3/full/npp2009188a.html
This is interesting. We know so little about the widespread effects of these drugs. Just because the drug directly affects one target, does not mean that other targets, modified more slowly by changes to gene transcription, are not the more active targets.
Linkadge
poster:linkadge
thread:1087015
URL: http://www.dr-bob.org/babble/20160306/msgs/1087141.html