Posted by Bill82 on May 6, 2015, at 23:13:33
In reply to Re: Possible drug approaches to hit Glutamate?, posted by SLS on May 6, 2015, at 11:24:25
Glutamate based drugs on the market currently are
1) Riluszole-hard to get prescribed and exspensive
2) memantine- shown some efgevtivness for OCD, but did not work for me, and seems to not have worked for you either.
3) Lamotragine-primarily based upon sodium channel blockade but also is a glutamate antagonist. Some reports of success with this drug in OCD.
4) topimirate-NMDA antagonist, but has shown to only affect compulsions in OCD and not obsessions. Also somewhat intolerable memory side effects
5) Amantadine-dopamine agonist(they think) and nmda antagonist similar to memantine but purported to affect different regions of the brain and therefore possibly different.
6) N Acytlc Cystine- supplement able to be bought over the counter, increases glutamate transmission, shown to have some effect in OCD
7) Glycine/Sarcosine- co agonist of glutamate at nmda receptor shown to have effects in some OCD patients as augmentation.
8) glyx13/rapastinel - new intravenously administered drug for depression also being looked at for OCD. Is a glycine site partial agonist.Think that's most of them could be more. I found none to help my OCD, and I like you was unresponsive to ssris. Also 5ht2a agonism over a long term setting downregulates glutamate transmission, so lexapro in a way does effect glutamate.
Another possibility is to use higher than normal doses of ssris if you tolerate them fairly well. For example, lexapro was shown to have best effect for OCD at doses around 40mg
5)
poster:Bill82
thread:1078701
URL: http://www.dr-bob.org/babble/20150407/msgs/1078724.html