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Re: Neurobiology of OCD - speculation

Posted by SLS on March 6, 2015, at 9:09:30

In reply to Re: Neurobiology of OCD - speculation, posted by Bill82 on March 5, 2015, at 16:18:42

There are some ongoing studies looking at ketamine for OCD.

I tried intranasal ketamine. It didn't help with depression, but it didn't make it worse, either. Have you tried memantine? Ketamine blocks glutamate NMDA receptors in a manner that is different from memantine, but it would interesting to investigate. Important to consider is that ketamine might not even work via the NMDA receptor. It might modulate glutamate activity via its active metabolite, hydroxynorketamine (HNK), which does not act on NMDA receptors.

Have you ever tried gabapentin or pregabalin? They work to inhibit calcium channels by attaching to he alpha2delta site.

Naltrexone is a very interesting idea for OCD. LDN made my depression worse, though.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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