Posted by ed_uk2010 on February 25, 2015, at 18:50:53
In reply to Re: Neurobiology of OCD - speculation, posted by Bill82 on February 25, 2015, at 11:50:01
>Not that it's blocked, but my genetic testing showed it's already under active, enough so that it's a gene associated with low responses to ssris. Which would also mean theoretically I may have more seritonin than usual and that seritonin isn't the main problem.
If your brain has developed from birth with an underactive serotonin reuptake system, it may have adapted to this in some way, perhaps by reducing serotonin release or receptor sensitivity.
>I have heard of people getting addicted to tramadol, and that it only helps ocd for a little while then tolerance builds like most opiates
It has a high potential for physical dependence and withdrawal symptoms. It was originally introduced as a med with little risk of dependence, and doctors prescribed it widely. Unfortunately, the dependence risk had been underestimated. It has recently been made a controlled drug over here. Given your issues with opiates in the past, it cannot really be recommended for you.
poster:ed_uk2010
thread:1075804
URL: http://www.dr-bob.org/babble/20150223/msgs/1077114.html