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Re: Starting Parnate after 15 yrs treatment-resistance Robert_Burton_1621

Posted by baseball55 on February 4, 2015, at 19:57:18

In reply to Starting Parnate after 15 yrs treatment-resistance, posted by Robert_Burton_1621 on February 4, 2015, at 2:55:13

> I would be interested to hear from anyone who's taking or has taken the drug about your experience of its efficacy, side-effects, as well as onset (and duration of sustained) therapeutic action.
>
10mg is a low dose. 30 mg is the usual starting dose.
I took parnate when almost catatonic from depression and was up and about - not all better, but functioning for the first time in months - within 48 hours. It never really got completely rid of my depression, but I never again fell into that vegetative state while on parnate. It started not holding me after about 3 years. But intensive work with a DBT/CBT therapist kept me stable and, after 4 years, I stopped the parnate.

Side effects. For me, the only really noticeable and problematic side effects were postural hypotension and insomnia. My p-doc prescribed ativan (lorazapem) for sleep, which really worked, so that helped the insomnia. Tapering off lorazapem though caused rebound insomnia for a while. Nothing's perfect.

As for the postural hypotension, I just had to take care. When getting out of bed, I sat up for several seconds, stood up and held onto the dresser for several seconds. It wasn't hard to remember to do this, because in the first few weeks, I fell a few times. So I became very careful. This problem went away over several months, but it never went away completely. I had hip surgery a couple of years into parnate and was surprised to discover, when the visiting nurse checked my BP, that it plunged when I stood up. I don't know. Maybe my body just adjusted itself to this. I no longer got dizzy.

Don't worry overmuch about the food interactions. People get neurotic about this, but it's not such a big deal

Good luck!


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