Posted by SLS on December 5, 2014, at 20:11:56
In reply to Re: What If We're Wrong About Depression? » Hugh, posted by brynb on December 5, 2014, at 13:26:25
A lack of resilience has been linked to an overactive medial prefrontal cortex (mPFC). This might explain the efficacy of deep brain stimulation (DBS) to treat depression. "Stimulation" is a misnomer. DBS actually interrupts - or "jams" - neuronal signals to prevent overactivity.
Mindfulness training and regular meditation might be helpful. Both seem to reduce mPFC activity and the strength of neural connections there.
Have you ever tried Lamictal or Topamax? I am guessing that drugs that reduce glutamatergic neurotransmission would help reduce mPFC overactivity, and thus, depression. I am also guessing that both of these drugs might work better when combinined with Abilify.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1073833
URL: http://www.dr-bob.org/babble/20141120/msgs/1073975.html