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Re: About SSRI-induced apathy

Posted by Louisiana Sportsman on April 26, 2014, at 18:04:22

In reply to Re: About SSRI-induced apathy » LouisianaSportsman, posted by klein on April 26, 2014, at 1:49:54

I'm sure it wasn't a placebo effect, and maybe I was grumpy.

You didn't have to cite papers defining apathy and possible dopaminergic deficit. Let's cut to the chase.

Any addicting behavior is going to be dopaminergic in some regard or it wouldn't be so addicting and basically glutamate/NMDA mediates the activity of a wide spectrum of assorted goodies and are essential part of how your brain is able to function.

This is not news.


>
There's one catch though, this strategy might only work for people who are already taking a regular dose of benzos due to some complicated interplay between regular benzo intake and glutmatate/NMDA, which is ultimately responsible for the dopamine boost.
>

No, it has nothing to do with benzo intake.

>
Tex's might have been right about those speculated receptors too, I'm thinking about the effect of enzos on NMDA receptors. Not to mention interneurons.
>

Which interneurons? Sounds like you're grasping for straws here.

A benzodiazepine is counterintuitive to reduce apathy. It's like getting someone too drunk to care as an extreme example, it's going to end making the situation worse. Why not methylphenidate?


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poster:Louisiana Sportsman thread:1064752
URL: http://www.dr-bob.org/babble/20140419/msgs/1064813.html