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Re: replace Abilify with perphenazine?

Posted by Louisiana Sportsman on April 14, 2014, at 18:44:54

In reply to Re: replace Abilify with perphenazine? » LouisianaSportsman, posted by ed_uk2010 on April 14, 2014, at 15:23:21

> >#120
>
> Isn't the number of tabs/caps up to the prescriber? A smaller quantity may be useful initially to assess response.

Well, that's a basic concept of psychopharmacology. I'm aware of that, ed_uk2010, but thanks for reminding me.

I was converting her oxcarbamazepine IR dosage to carbamazepine ER if she was to theoretically switch to Equetro which is a time-released carbamazepine that is indicated for the treatment of acute manic and mixed episodes associated with bipolar disorder.

She currently is taking the instant release metabolite of carbamazepine, oxcarbamazepine (Trileptal), which is indicated for seizures. An equipotent dosage of carbamazepine to her current dosage of 1,200mg. oxcarbamazepine is 800mg. of carbamazepine.

Equetro is only supplied in capsule formations of 100, 200 and 300mg., respectively. To receive a 800mg. dosage of Equetro equivalent to Trileptal, the lowest quantity dispensed equal to 800mg. is #120 200mg. capsules. (200mg. x 4 capsules = 800mg. x 30 days in a month = #120)

Yes, ed_uk2010, smaller quantities are useful in psychiatry, but in this case, I was just doing a conversion. I thought it was useful.

I'm not sure why she'd need a smaller dosage of a mood stabilizer that she has already assessed just in a different formation; essentially, why would she need to assess a smaller dosage if she has already responded to that equipotent dosage of the metabolite? I guess you may have a different opinion and that's OK.


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poster:Louisiana Sportsman thread:1063976
URL: http://www.dr-bob.org/babble/20140328/msgs/1064212.html