Posted by Franz on February 18, 2014, at 7:56:28
In reply to Re: solution? Re: Modafinil only worsens my depression » Franz, posted by SLS on February 17, 2014, at 14:24:54
> > Wow. I did a search on "modafinil depression" on this site and came to this thread. I have similar effects. First 50-100 mg are good (more alert, talkative, but not much motivation) but at the end of the day I feel bad. Dyshporic is a good term as mentioned. Bad thoughts, pessimistic, guilt, etc. Of course my Dr and psychologist do not understand. Most stimulants (caffeine, I have not tried many) let me tired, but this one has a plus of sadness.
> >
> > Anyone can give an explanation? I read that it raises all neurotransmitters except GABA, which lowers. I take a small dose alprazolam at night. Maybe more benzo during the day can help or will that negate the effects of modafinil?
>
> I would consider discontinuing the modafinil. I doubt that there is any kind of trick you can use to reverse your negative reaction to it. Perhaps microdoses? Modafinil affected me in much the same way as it did you. In fact, it left me more depressed and in a brain fog for a few weeks after discontinuation. I now use Focalin (dexmethylphenidate) for days when I am especially anergic and demonstrate cognitive slowing and flat affect. It works pretty well. For me, the onset of clinical effect occurs approximately one hour after the dosing, and lasts for about five hours.
>
> Have you tried Parnate, Effexor, or Wellbutrin?
>
>
> - ScottThanks Scott.
The microdoses is a good idea, although the pill is difficult to cut and tastes horrible. I read some people take 25 or 12.5 mg
Maybe the problem with modafinil is that it interacts with coffee. I don't drink much coffee but I need a couple of small cups a day.
I have tried SSRI with either poor results (lethargy from escitalopram) or tinnitus (fuoxetine). Wellbutrin my Dr said I will not tolerate, maybe he thinks it will cause anxiety.
I was thinking in trying selegiline (deprenyl) again. I remember it also made me feel tired.
dexmethylphenidate I don't think I will be prescribed because I asked if there were other stimulants I could try instead of modafinil and said no. Maybe he thinks it is addictive or he is not skilled at using it.
poster:Franz
thread:923905
URL: http://www.dr-bob.org/babble/20140214/msgs/1060830.html