Posted by Bob on January 29, 2014, at 14:17:18
In reply to Re: Switching from Abilify to Latuda » Bob, posted by SLS on January 29, 2014, at 14:02:00
> >
> > Latuda also seems to be causing fatigue and has totally crushed my sexuality -- not that it wasn't almost gone already with my base cocktail of nortriptyline and sertraline.
> >
> > I've tried adding Wellbutrin as well as Nuvigil but both don't have sustainable benefits for me.
> >
> > Bob
>
> That is not an optimistic report. :-(
>
My doctor will not touch the MAOI+nortriptyline combo that you are taking. He says mixing NRIs with MAOIs is dangerous. What about stimulants, are they okay to take with an MAOI?
> Why are you taking an antpsychotic?
>
> Have you tried Abilify?
>
> Right now, I am pleasantly surprised that I have not dropped off for having discontinued Abilify. I don't know. Perhaps Latuda is making an effective substitute. I am not feeling too much better, but I don't think I am feeling worse. I thought I needed the dopamine activation provided by Abilify when treating depression (DA D2/D3 partial agonist). I really thought that I would significantly relapse. It's still early yet, of course, but I am hoping for magic. Latuda is not a DA partial agonist, but it is a 5-HT7 receptor antagonist. Recently, this receptor has been the focus of interest in accounting for the antidepressant effects of Latuda.
>
> I hope you are experiencing a temporary setback. Who knows what your brain is up to. Have you ever tried Focalin for fatigue / brain fog? It helps me when my energy ebbs. If it is a good drug for you, you won't experience a depressive rebound when it wears off. For now, I am using it occasionally in place of caffeine. My doctor prescribed it to be taken on a daily basis in the hope that it will kick-start a robust antidepressant response. I want to see how Latuda treats me first.
>
> Please continue posting.
>
> Me:
>
> Parnate 100 mg/day
> nortriptyline 150 mg/day
> Lamictal 200 mg/day
> lithium 450 mg/day
> Latuda 40 mg/day
> prazosin 25 mg/day
> minocycline 200 mg/day
>
>
> - Scott
>
>
>
poster:Bob
thread:1059698
URL: http://www.dr-bob.org/babble/20140123/msgs/1059901.html