Posted by SLS on January 29, 2014, at 14:02:00
In reply to Re: Switching from Abilify to Latuda » Bob, posted by Bob on January 29, 2014, at 12:53:36
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> Latuda also seems to be causing fatigue and has totally crushed my sexuality -- not that it wasn't almost gone already with my base cocktail of nortriptyline and sertraline.
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> I've tried adding Wellbutrin as well as Nuvigil but both don't have sustainable benefits for me.
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> BobThat is not an optimistic report. :-(
Why are you taking an antpsychotic?
Have you tried Abilify?
Right now, I am pleasantly surprised that I have not dropped off for having discontinued Abilify. I don't know. Perhaps Latuda is making an effective substitute. I am not feeling too much better, but I don't think I am feeling worse. I thought I needed the dopamine activation provided by Abilify when treating depression (DA D2/D3 partial agonist). I really thought that I would significantly relapse. It's still early yet, of course, but I am hoping for magic. Latuda is not a DA partial agonist, but it is a 5-HT7 receptor antagonist. Recently, this receptor has been the focus of interest in accounting for the antidepressant effects of Latuda.
I hope you are experiencing a temporary setback. Who knows what your brain is up to. Have you ever tried Focalin for fatigue / brain fog? It helps me when my energy ebbs. If it is a good drug for you, you won't experience a depressive rebound when it wears off. For now, I am using it occasionally in place of caffeine. My doctor prescribed it to be taken on a daily basis in the hope that it will kick-start a robust antidepressant response. I want to see how Latuda treats me first.
Please continue posting.
Me:
Parnate 100 mg/day
nortriptyline 150 mg/day
Lamictal 200 mg/day
lithium 450 mg/day
Latuda 40 mg/day
prazosin 25 mg/day
minocycline 200 mg/day
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1059698
URL: http://www.dr-bob.org/babble/20140123/msgs/1059899.html