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Antipsychotics and Brain Volume SLS

Posted by doxogenic boy on September 25, 2013, at 15:37:44

In reply to Re: Thoughts on AAPs please... phidippus, posted by SLS on September 24, 2013, at 14:55:03

Here is an article from Archives of General Psychiatry that shows that antipsychotics decrease brain voume. It is the same with atypical and typical antipsychotics:

Excerpt from article:
Viewed together with data from animal studies, our study suggests that antipsychotics have a
subtle but measurable influence on brain tissue loss over time, suggesting the importance of careful risk-benefit review of dosage and duration of treatment as well as their off-label use.
Arch Gen Psychiatry. 2011;68(2):128-137

Excerpt from article:
Arch Gen Psychiatry. 2011;68(2):126-127. doi:10.1001/archgenpsychiatry.2010.187

Since the initiation of antipsychotic drug therapy for schizophrenia,clinical
observations and empirical studies have demonstrated that these medications bring benefit and harm. Consequently, efforts to develop new antipsychotic medications during the past 50 years have been motivated, at least partly, by the desire to enhance the benefit to harm ratio
relative to existing medications.

In this issue of the Archives, Ho and colleagues 1 examine one arm of this ratio by asking whether antipsychotic medications contribute to progressive brain volume reductions in schizophrenia. Individuals early in the course of schizophrenia (n = 211) were treated with antipsychotic medications according to standard
clinical practice and followed up longitudinally with clinical assessments and serial magnetic resonance imaging (MRI)scans (between 2 and 5 scans per individual) for a mean of 7 years.
The authors found that the amount of exposure to antipsychotic medication predicted decrements
in cerebral gray and white matter volumes and increased the volume of the putamen. Illness duration and severity were also associated with smaller brain volume measures, but the relationship between antipsychotic medication
use and brain volume remained significant after accounting for the effects of illness severity and
duration and substance abuse history. Interestingly, changes in brain volume with
time were similar for all classes of antipsychotic medications (ie, typical
antipsychotics, atypical [ie, excluding clozapine] antipsychotics,and clozapine).
End quote

- doxogenic

Earlier TRD/anxiety
300 mg tianeptine, 6 X 50 mg successfully since Oct 2009
20 mcg liothyronine
40 mg escitalopram
100 mg trimipramine
50 mg agomelatine
600 mg quetiapine




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