Posted by SLS on December 29, 2012, at 21:26:48
In reply to Re: GGG Unit » SLS, posted by ed_uk2010 on December 29, 2012, at 13:23:28
> > You might be a prazosin responder.
> Good idea :) Also, I wonder whether prazosin would work for GGG as an augmenting agent to nortriptyline, Strattera or other NE reuptake inhibitorsYou've been doing your homework.
According to one lab model of depression, prazosin enhanced the antidepressant effect of desipramine, but not Prozac. Using another model, Prozac was effective, too. I would be more inclined to try a NRI like desipramine as you suggest.
> and reduce the insomnia and overstimulation that occured.
Yes.
> Might also augment Parnate but would certainly have to beware of orthostatic hypotension.
For me, the dizziness produced by the addition of prazosin to Parnate was fleeting. However, I started treatment at 1 mg/day given at night to reduce the chances of dizziness from occurring during the day. I did this for two days, and then increased by 1 mg every two days in divided doses until I reached 6 mg/day. At that point, I was able to accelerate titration up until 20 mg/day. I have since found that 15 mg/day is ideal for me. 20 mg/day produced somnolence and sedation. Prazosin should be dosed 3 times a day. During the first week, I experienced some somnolence and dizziness. Both side effects disappeared completely. The only side effect that remains is reduced sexual libido.
If you don't mind my asking, what medications are you currently taking, and how are you feeling?
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1034023
URL: http://www.dr-bob.org/babble/20121217/msgs/1034178.html