Posted by SLS on December 28, 2012, at 8:45:18
In reply to Re: GGG Unit » jono_in_adelaide, posted by g_g_g_unit on December 28, 2012, at 7:15:39
> Mirtazapine: GOOD: helped sleep at 15mg .. BAD: worst drug ever for my OCD at 30mg, became dysphoric and suicidal
You might be a prazosin responder.
NE alpha-2 receptor antagonists affect me very badly and might indicate hyperactivity in certain noradrenergic circuits. If this is true, then, prazosin should reduce depression. In the amygdala, prazosin would reduce anxiety. In the nucleus accumbens, prazosin would elevate mood, enhance reward, and reduce anhedonia. This is pretty theoretical stuff. You won't know if prazosin will help until you try it. It is a very clean drug with the exception of reduced libido. Startup side effects include dizziness and somnolence, but these things disappear within a week as long as you titrate gradually.
I am not convinced that you are a "slow metabolizer" of every drug you try. I think it is more likely that you just have a brain that is sensitive to change.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1034023
URL: http://www.dr-bob.org/babble/20121217/msgs/1034057.html