Posted by delna on November 17, 2012, at 1:26:52
Hi Scott and anyone reading this message who can please help:
I really need your in depth knowledge to solve something. But only if you feel up to it.
I'll first ask my question before bombarding you with details.
I am looking to find out
"What do sulpiride (at low dose of 50mg) and Geodon share in common which is rare and not shared by many drugs including stimulants. Or perhaps they jut act in a different area of the brain than other drugs. Where could that be?The background:
I don't know if you recall me and my obsession with Geodon. It is the only drug that had a sustained effect and made me 100% normal. Functional- with a job, a life and the will to live. Its the activating property of Geodon that was a miracle for me. And at 60mg, it also stabilized me. Then it worsened a preexisting nerve hypersensitivity and in spite of high dose of gabapentin 3600mg the pain kept breaking through. Eventually the pain got out of hand and I was forced to give it up. I tried everything for the pain, including nerve blocks but nothing worked.
I tried other things but nothing helped. Parnate also failed. So I tried to mimic Geodon by replicating the known positive binding sites. I remember getting lots of advise here on trying ways to mimic the receptor binding but that failed.To mimic Geodon, various drugs were tried;
-The activating property of Geodon is apparently due to activity at 5HT-2C. Prozac is the only other drug with such strong binding at this site. (stahl).
I tried Prozac with no activation and no improvement of depression
-The other unique receptor in Geodon is 5HT-1A
Buspar shares this binding. I took 30mg of Buspar, for ages with no benefit
Geodon also has strong activity at NA receptors. This seemed to account for the energizing property of Geodon according to books. But I don't think this was the case for me. Because all the NA and DA enhancers are not a patch on the activation I had on Geodon. By that I mean that stimulants just prop me up like a rag doll, held up by strings. I'm still brain dead where as with Geodon and initially with Sulpiride, a light switched on in my brain. Both helped depression and drive. My brain was awakened and I felt like living.As of now I am taking the sulphide which has more or less pooped out and am managed of several drugs that potently effect NA and/or DA receptors: To stay wake, (just about) this is what I take daily. (But none lift depression or wake my brain up and make me feel like living):
Ritalin 40mg,
Dexedrine 20mg,
Provigil 400mg,
Effexor 150mg, (seemed useless so reduced to 37.5 just to prevent OCD from coming back)
Bupropion 450mg,
Reboxetine 8mg (NARI)
Raising these doses really does not help. Its like I'm attacking the wrong pathway. I have also wondered if I am absorbing these drugs at all! There was a time when 2.5mg Ritalin make me manic (in a bad way) and I would be destabilized long after I stopped.Then my usual drugs
Effexor (for OCD)
Lamictal 200mg
Klonopin 2mg (for nerve pain)I was so low before the addition of Sulpiride I attempted suicide but managed to screw that up. Just before giving me ECT, Sulpiride 50mg was added to the combination above and what a dramatic effect it had! I felt fine a lot like Geodon- I had energy, I was not blah and my brain woke up. And the depression lifted.
Unfortunately 2 weeks in, my mood went haywire. I discovered that my prolactin had shot up. Sulpirides efficacy is negatively affected by high prolactin, which in itself ruins mood and energy. It took ages to bring prolactin down (I am on 20mg bromocriptine for that) but Sulpiride has not regained its initial effects, ever. It seems to have pooped out, which is common I believe. It still has a minimal but significant effect and is one of the most activating drugs in my regime. Id be willing to remove a stimulant but not the Sulpiride .Without it, the stimulants are incapable of doing much to help me stay awake and able to do minimal things. I tried replacing it with ability (due to the awful weight gain) but that was a failure.
While Geodon has binding at 5ht-7, low dose Sulpiride doesnt. But I have not tried 5ht-7 enhancement
I am convinced there is something involving DA disinhibition in a certain part of the brain where stimulants dont act.Or maybe I just need to try Latuda....
I am going to try the minocycline but I really have a feeling this is more to do with my drugs not being the most effective.
Please excuse my inaccurate scientific words. I'm not 'all there'
poster:delna
thread:1031452
URL: http://www.dr-bob.org/babble/20121113/msgs/1031452.html