Posted by jono_in_adelaide on August 30, 2012, at 18:55:36
In reply to Re: Nortriptyline, Buspar, Serotonin - SLS, posted by jono_in_adelaide on August 30, 2012, at 18:46:36
I changed to reboxetine + sertraline because the nortriptyline had contributed to weight gain (or maybe I had just gained weight and blamed the nortriptyline).... I found them about equal in antidepressant effect.
It makes more sense to me to use an SSRI + nortriptyline/reboxetine than Effexor, because the SSRI will be a robust inhibitor of seretonin reuptake and the nortriptyline will be a robust inhibitor of noradrenalin reuptake, where as Effexor is a strong inhibitor of seretonin and only a weak inhibitor of noradrenalin reuptake in the usualy used doseages.
Plus nortriptyline hts the 5HT2 receptor, which gives some additional antidepressant and anxiolytic effect
poster:jono_in_adelaide
thread:1024421
URL: http://www.dr-bob.org/babble/20120830/msgs/1024491.html