Posted by SLS on August 30, 2012, at 15:42:12
In reply to Re: Nortriptyline, Buspar, Serotonin » SLS, posted by schleprock on August 30, 2012, at 11:00:14
> > > Buspar blocks seretonin receptors, it soesnt inhibit reuoptake, so I doubt nortriptyline + buspar would = clominramine
> > >
> > > nortriptyline + sertaline or another ssri *might* work, but realy, the only substitute for clomipramins is more clomipramine
> >
> > Buspar is infrequently used as an augmenter to SSRIs. It is a partial agonsist at serotonin 5-HT1a receptors, as is Viibryd. Viibryd might therefore confer anxiolytic as well as antidpressant properties. The SSRI component of Viibryd is fairly potent, and from reports, acts to alleviate OCD. Viibryd is like a combination of SSRI + Buspar, but without the D2 antagonism. Personally, I found Viibryd to be a rather clean drug without the usual SSRI side effects of apathy and flat affect. Happily, there were no sexual side effects either. In combination with nortriptyline, Viibryd might act much like clomipramine. On paper, it is an interesting proposition. I believe the therapeutic window for this combination will be wider than with clomipramine, as side effects often limit clomipramine use. Studies of adding nortriptyline to a SSRI - or even clomipramine - demonstrates an earlier onset of clinical improvement and greater reduction in symptoms of OCD.
> >
> > journals.tums.ac.ir/pdf/3511
> >
> > http://www.ncbi.nlm.nih.gov/pubmed/9786103
> >
> > www.irmj.ir/browse.php?a_id=131&slc_lang=en&sid=1...
> >
> >
> > - Scott
>
> I'm still not sure, but by being an "agonist" would Buspar, however slightly, raise the amount of serotonin?- Receptor = a site upon which specific molecules bind to.
- Ligand = a molecule that attaches to a receptor.
- Agonist = a ligand that stimulates a receptor to act.
- Antagonist = a ligand that blocks a receptor and inhibits it from acting.
- Partial agonist = a ligand that acts as a buffer at the receptor. It can both stimulate and inhibit it, depending on the receptor location, conformational state, and synaptic neurotransmitter concentration.http://www.healthieryou.com/mhexpert/exp1041502a.html
> I already had a bad experience trying to switch over to clomipramine
What happened?
> I think I have to try something more mild. I have a lot of symptoms that are consistant with low serotonin,
Which symptoms?
> but not OCD.
Okay.
> SLS, are you currently on an effective regimen that includes nortriptyline?
Yes.
Parnate 80 mg/day
nortriptyline 150 mg/day
Lamictal 200 mg/day
lithium 300 mg/day
Abilify 10 mg/day
minocycline 100 mg/dayI am currently experiencing a moderate antidepressant response that seems to be improving day by day. It is the addition of minocycline that has accelerated the rate of my recovery. I have been able to discontinue prazosin for now. I am doing better on minocycline than I was on prazosin. If the course of my improvement stalls, I will add back the prazosin. There is evidence that minocycline can work to augment an anti-glutamatergic drug (Lamictal) and a pro-noradrenergic drug (nortriptyline).
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1024421
URL: http://www.dr-bob.org/babble/20120830/msgs/1024474.html