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Re: help- trazodone stopped working novelagent

Posted by SLS on August 22, 2012, at 6:30:18

In reply to help- trazodone stopped working, posted by novelagent on August 22, 2012, at 2:11:31

> I've never had a med stop working before, but Trazodone 100mg doesn't work anymore after starting it 3weeks ago. What else is there? I have sexual dysfunction from Effezor-- is Remeron going to let me heal from that, or is it enough like effexor to prolong the damage? I vaguely think i recall it's sometimes used for sex dysfunction-- isn't it a partial dopamine agonist?
> I'd take seroquel, but I'm already on Invega Sustenna injections. I'm out of ideas. Unisom isn't doing anything, and melatonin doesn't work for me. Ambien is off the table, because I have a community clinic doc, and everyone knows they don't prescribe meds that work (klonopin also off table).

Why was trazodone prescribed? How did it affect you?

Have you thought to try nefazodone?

For how long did you take Effexor? You can try adding Wellbutrin to Effexor if anxiety isn't a problem. It would make Effexor work better for depression and help to remediate sexual dysfunction. The combination can be very effective to treat depression, especially atypical or anergic subtypes.

If Effexor works well, you can also try adding buspirone to help ameliorate sexual dysfunction. It might even help with depression.




Viibryd (vilazodone) would be an interesting choice for you. It is an SSRI / 5-HT1a partial agonist that does not tend to produce sexual side effects.

Using Remeron as an adjunct to Effexor might be exactly the right thing to do according to some people. The combination was once popular and known as "California Rocket Fuel". I am not sure about the capacity of Remeron to reduce sexual impairments. If arousal and anorgasmia are issues, cyproheptadine (Periactin) can be taken just before having sex. It can be sedating, though. Periactin and Remeron both antagonize 5-HT2a/c receptors. However, Periactin also antagonizes 5-HT2b receptors, which is an important property to improve sexual function.

Buspar (buspirone) is often chosen as a remedy for SRI-induced sexual impairments. It can also enhance the therapeutic response to antidepressants and reduce sexual impairments.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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