Posted by phidippus on August 13, 2012, at 12:42:41
In reply to lyrica - how does it work, posted by cee on August 12, 2012, at 17:45:24
I never used it for depression, however I have used it to treat anxiety and OCD with fair results.
pregabalin binds to the α2δ (alpha2delta) subunit of the voltage-dependent calcium channel in the central nervous system. Pregabalin decreases the release of neurotransmitters including glutamate, noradrenaline, substance P and calcitonin gene-related peptide. However, unlike anxiolytic compounds (eg, benzodiazepines) which exert their therapeutic effects through binding to GABAA, GABAB, and benzodiazepine receptors, pregabalin neither binds directly to these receptors nor augments GABAA currents or affects GABA metabolism.