Posted by SLS on August 13, 2012, at 6:25:30
In reply to Re: lyrica - how does it work, posted by rjlockhart37 on August 12, 2012, at 21:15:19
> similar to nuerontin.....well its its sister drug...anyways, it reduces firing by using the GABA receptors but it doesnt do the benzo thing...its unique how it works because of pain relief and mood aspects, it has been known to improve mood, but mainly its used for anxiety when benzos are not considered.
Never again say that you are somehow below average in intelligence!
I don't think it is yet clear how Neurontin works. I think it depends on which circuits are being examined. It hurts my brain whenever I attempt to figure it out.
I doubt Neurontin modulates GABA receptors directly. However, it does binds to the alpha2delta subunit of voltage-gated calcium channels found on catecholaminergic neurons. It does not block calcium entry through the channel when administered acutely (although it might do so if applied chronically). Acute Neurontin application does reduce the amount of neurotransmitter released through vesicular fusion with the presynaptic membrane. Neurontin also interacts with the opioid system.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1023132
URL: http://www.dr-bob.org/babble/20120803/msgs/1023177.html