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Re: Buprenorphine(suboxone) for anxiety, depression... Diego11

Posted by SLS on July 26, 2012, at 6:47:57

In reply to Buprenorphine(suboxone) for anxiety, depression..., posted by Diego11 on July 26, 2012, at 5:52:50

> I wonder, if there is any PHARMACOLOGICAL STUDY about buprenorphine (suboxone) for anxiety, SP, depression (as off-label treatment of Social phobia and depression) ? I am looking for a study - research with using this drug for the above mentioned disorders. I need something believable to convince my doctor about possibility of this off-label treatment for me.
>
> I also wonder, if anyone has any experience with taking buprenorphine in long term (off-label) treatment of anxiety, depression ?


Aside from a paper written in 1995, I am unaware of any peer-reviewed investigations into the use of buprenorphine in the treatment of depression.


- Scott

--------------------------

J Clin Psychopharmacol. 1995 Feb;15(1):49-57.
Buprenorphine treatment of refractory depression.
Bodkin JA, Zornberg GL, Lukas SE, Cole JO.
Source

McLean Hospital, Consolidated Department of Psychiatry, Harvard Medical School, Belmont, MA 02178, USA.
Abstract

Opiates were used to treat major depression until the mid-1950s. The advent of opioids with mixed agonist-antagonist or partial agonist activity, with reduced dependence and abuse liabilities, has made possible the reevaluation of opioids for this indication. This is of potential importance for the population of depressed patients who are unresponsive to or intolerant of conventional antidepressant agents. Ten subjects with treatment-refractory, unipolar, nonpsychotic, major depression were treated with the opioid partial agonist buprenorphine in an open-label study. Three subjects were unable to tolerate more than two doses because of side effects including malaise, nausea, and dysphoria. The remaining seven completed 4 to 6 weeks of treatment and as a group showed clinically striking improvement in both subjective and objective measures of depression. Much of this improvement was observed by the end of 1 week of treatment and persisted throughout the trial. Four subjects achieved complete remission of symptoms by the end of the trial (Hamilton Rating Scale for Depression scores < or = 6), two were moderately improved, and one deteriorated. These findings suggest a possible role for buprenorphine in treating refractory depression.

PMID:
7714228
[PubMed - indexed for MEDLINE]

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