Posted by bleauberry on May 1, 2012, at 7:37:32
In reply to Re: i cant even smile., posted by SLS on April 29, 2012, at 18:52:08
Maybe. Maybe not. I have never seen anything in writing that would suggest that but ok. You know your stuff so I will take that as fully trustable at face value. Maybe lower doses of a TCA+SSRI combo might be more attractive than a monster dose of effexor.
> > That is correct and thank you for pointing out the error. Zoloft has some dopamine impact at very high doses, you mentioned effexor, and such. I guess what I should have said is the meds are basically fixed ratios with some mild to modest variation dependent upon the size of the dose. While effexor impacts NE heavier above 300mg roughly, that impact is still very small compared to its impact on serotonin.
> >
> > > > With any med however, the ratio is fixed.
> > >
>
> The binding affinities might be fixed, but not the absolute occupancy. If you were to bring the dosage of Effexor high enough, the ratio of occupancy might approach 1:1.
>
>
> - Scott
poster:bleauberry
thread:1016383
URL: http://www.dr-bob.org/babble/20120425/msgs/1016834.html