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Lou's reply-FDA report-saphris

Posted by Lou Pilder on February 27, 2012, at 22:18:00

In reply to Lou's reply-agranulocytosis » SLS, posted by Lou Pilder on February 27, 2012, at 22:10:29

> > > Now in relation to saphris, as to what the drug is and such, and what it can do to the taker of the drug, I would like to introduce in the expsition the drug known as {Fenfluramine}.
> >
> > Okay.
> >
> > > Now another drug called {phentermine} combined with (fenfluramine), gives a drug called Phen-fen.
> > > This drug has been taken off the market
> >
> > Also, fenfluramine itself has been taken off of the market.
> >
> > > because of how it could cause heart disease and death.
> >
> > Yes. Valvulopathy. Also, pulmonary hypertension if my memory serves me.
> >
> > Fenfluramine is a dangerous drug.
> >
> > > Now the drug Saphris activates in one way or another some of the same receptors as fenfluramine.
> >
> > To the best of my knowledge, this is misinformation.
> >
> > Fenfluramine is a serotonin releaser that activates many different serotonin (5-HT) receptors. Asenapine acivates only one serotonin receptor - 5-HT1a. The mechanism by which fenfluramine causes adverse heart effects is via 5-HT2b receptor activation. Saphris and fenfluramine are not alike in this respect.
> >
> > > So if you read the Saphris PI there could be the disclosure of possible agranulosis.
> >
> > To the best of my knowledge, agranulocytosis is not an adverse effect of Saphris.
> >
> > Agranulocytosis is listed on the PI only because other drugs in its class have this side effect. Can you prove that a single case of agranulocyctosis has occurred with Saphris? I couldn't find a single case on Medline/Pubmed.
> >
> > > In the clinical trials, there were many deaths.
> >
> > To the best of my knowledge, this is misinformation.
> >
> > Please provide citations for this statement.
> >
> > Your use of the word "many" is an exagerration.
> >
> > To the best of my knowledge the 3-post rule still applies. Life is good.
> >
> >
> > - Scott
>
> Scott,
> https://www.druginformer.com/search/side_effect_details/saphris/agranulocytosis.html

Scott and friends,
Here is the FDA report regarding saphris. It is over 1000 pages so your system may not bring this up. It will take a long time...acrobat
Now I have highlights of the report that I will post later...
Lou
UCM173877
or
UCM123877

 

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poster:Lou Pilder thread:1011122
URL: http://www.dr-bob.org/babble/20120221/msgs/1011868.html