Posted by SLS on February 12, 2012, at 6:31:11
In reply to Cariprazine » SLS, posted by ed_uk2010 on February 11, 2012, at 8:19:49
> Hi Scott,
> What do you think of the studies that I posted about above...
I think the most important feature of cariprazine is that it is much more potent as a partial agonist at dopamine D3 receptors than at D2 receptors (higher D3/D2 ratio). D3 is the receptor of pleasure and reward, and is found in the following regions of the brain:
- thalamic paraventricular nucleus
- nucleus accumbans
- ventral tegmental area
Without D3 receptors, cocaine would have no pleasurable effect. As a matter of fact, D3 partial agonists can act as a sort of muffler, thereby reducing cocaine's effect. It occurs to me that cariprazine might help with cocaine addiction in much the same way as buprenorphine, a mu opioid receptor partial agonist, does with opioid addiction. Just a thought...
Thanks for making me learn stuff.
Some see things as they are and ask why.
I dream of things that never were and ask why not.
- George Bernard Shaw