Posted by bleauberry on February 12, 2012, at 10:07:20
In reply to Does abilify work for anhedonia, posted by n_shrimpie on February 8, 2012, at 20:02:30
I have seen people report here of their experiences with abilify. Some of them did get a positive effect that looks like anti-anhedonia. Others report emotional numbness and flatness. I think it depends on the person's unique biology, the actual underlying cause of the psych symptoms (what disease or toxin is doing it?) and the size of the dose. Personally I would not think of abilify as an anti-anhedonia med. But anything is possible.
Treating anhedonia is a tough one I think. We tend to think of it as a dopamine thing, but my experience showed me norepinephrine plays a big role, maybe even more important than dopamine. But it's a concert....all things need to working in a balanced synergy, it's not just this or that. So it makes it hard to nail anhedonia.
My best anhedonia results came from savella, adrafanil, ritalin, vicodin, amisullpride. SSRI+TCA combos I think are worthy also, but doses need some experimentation for proper balance and the doses need to stay as low as possible.
You noticed more activation on abilify at lower doses and that is consistent with the drug's usual behavior. It is generally more activating at lower doses and more numbing at higher doses.