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Re: Adding Parnate and prazosin. » SLS

Posted by Bob on January 4, 2012, at 14:50:31

In reply to Re: Adding Parnate and prazosin. » Bob, posted by SLS on January 4, 2012, at 5:55:26


>
> Chronic (long-term) antidepressant treatment with certain drugs causes the norepinephrine NE alpha-1 receptors to downregulate by reducing their numbers. Prazosin blocks these same receptors, thereby producing the same net effect.
>
> - Scott
>


I'm still lost. Is causing NE alpha-1 receptors to downregulate a desired effect or something that that we are trying to offset? Logically it would seem to me that if you are blocking the receptors it would reduce the available NE to the brain?

Bob

 

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poster:Bob thread:1005781
URL: http://www.dr-bob.org/babble/20111226/msgs/1006332.html