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Re: Adding Parnate and prazosin. » SLS

Posted by sigismund on January 4, 2012, at 12:31:23

In reply to Re: Adding Parnate and prazosin. » Bob, posted by SLS on January 4, 2012, at 5:55:26

>Chronic (long-term) antidepressant treatment with certain drugs causes the norepinephrine NE alpha-1 receptors to downregulate by reducing their numbers.

I can see that could easily have happened to you.

>Prazosin blocks these same receptors, thereby producing the same net effect.

I'm lost here.

>For now, I would say that prazosin might work best as an adjunct to antidepressants for people who have a history of childhood physical abuse, emotional abuse (including bullying), or neglect. It may be that some people have a backdrop of PTSD acting to drive depression.

Prazosin is Minipress, right? I was wondering if it blocks overactive NE, or were you saying the reverse?

How has it affected your sleep? I wonder if my sleep is disrupted by too much NE. Certainly something is doing it. I'm not in a hurry to try clonidine.

 

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URL: http://www.dr-bob.org/babble/20111226/msgs/1006315.html