Posted by Seige on September 12, 2011, at 6:55:11
In reply to Re: Memantine + Parnate: Day 4 » Seige, posted by sigismund on September 11, 2011, at 22:11:58
> > but it is definitely stimulating and made sleep really light after a while.
>
> Yes, and if my experience is anything to go by, this gets worse over time.
>
> Tolerance seems to build more to the melatonin receptor agonism than the 5ht2c antagonism.
>
> I need to go back to half a tablet when I wake and see how I go.
>
>
I think that's the whole reason ago works - 5ht2c downregulating in response to antagonism, so yeah tolerance is nothing. Definitely got stronger over time.Also today was day 5 of parnate + Memantine. Could feel the parnate today, it was nice, was so sleepy and out of the IT the entire day though. It was still pleasant however, I a nice respite from feeling so flat since last time I started up parnate.
Also the opportunity to participate in trials for DCS have come up. You have to technically be in a depressive episode to qualify however, and I know at least for the next couple of weeks, I won't satisfy that. I wonder what the chances would be of DCS helping with anhedonia... Sounds like it would be a better long term option if it worked than trying to push back parnate tolerance.
poster:Seige
thread:996139
URL: http://www.dr-bob.org/babble/20110902/msgs/996533.html