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Re: Memantine + Parnate: Day 4 » Seige

Posted by Chairman_MAO on September 29, 2011, at 18:50:31

In reply to Memantine + Parnate: Day 4, posted by Seige on September 11, 2011, at 4:01:08

Get your dose up to 1.5mg/kg/day (maximum 200mg/day) in divided doses. I have no idea how you'd be able to pull this off, but see if you can get a compounding pharmacy to make a sustained (or extended!) release preparation.

IMHO (and it is humble and nobody cares, but I like people to feel better), if you've exhausted enough options to get to tranylcypromine, cut to the chase and go high-dose. There are fewer side effects. The drug and its metabolites do _so much more_ than inhibit MAO. Tranylcypromine is in a class by itself.

The major pain is that with the 10mg tabs, you have to somehow carry around 12-20 of them _per day_ and take 20-30mg doses every two hours or so in order to get a consistent effect.

Please, if anyone has the money, get someone to compound you an sustained/extended release preparation!

I cannot post copyrighted articles here but there is a rationale for this. Anyone who's really curious can contact me privately and I can explain ...

The memantine's a good idea. It is actually safe, believe it or not, to also [gingerly] add d-amphetamine to high-dose tranylcypromine. Still, even this outstanding treatment doesn't work for everyone, but it is absolutely nothing like most antidepressants. If our regulatory goons ever figured out how good it was possible to feel on tranylcypromine, it would get scheduled.


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poster:Chairman_MAO thread:996139
URL: http://www.dr-bob.org/babble/20110925/msgs/998289.html