Posted by linkadge on July 18, 2011, at 14:38:43
In reply to Re: cannabanoid CB1 agonists are neuroprotective, posted by SLS on July 18, 2011, at 9:07:00
>I wonder how many people are actually deficient >in endocannibinoids or their receptors. It may >be that this is a rare condition for which >remedial treatment is rarely desirable.
Perhaps, or it may be that this system has been underappreciated/underutilized in the treatment of certain disorders.
There is a clear hesitancy towards the study of this system in mood disorders, because of certain euphorogenic potential of cannabanoid agonists. It is the same with the nicotine acetylcholine system. Nicotine has documented neuroprotective effects, especially in terms of dopaminergic system neurotoxicity. This completely extends to exogeniously administered nicotine. However, there is some issue of dependance with nicotine.
>How does CB-1 agonists compare to lithium or >selegiine for neuroprotection?
There are a plethora of different potential avenues for neuroprotection.
>Marijuana intoxication is not a benign condition.
No, but nobody is advocating for a haphazard usage of the substance. I have been more impaired on other prescription medications (taken as directed) that I ever have by alcohol. It was 'legal' for me to drive on amitriptyline, zopcilone and trazodone, however it was an exceedingly risky venture.
The cananbanoid system has direct influence on mood, appetite, sleep and pain perception. The HPA regulating effects of TCA's have been directly linked to the cannabanoid system.
I have been battling treatment resistant, chronic insomnia for years.
All of the treatments that "work" suck miserably in terms of side effects. Amitriptyline seems to be a mainstay, but I am severely impaired by its side effects. Amitriptyline makes me paranoid, gives me cardiac side effects, makes me hung over the next day and disturbs my memory. Benzodiazapines "work" but eventually lead to crippling depression.
I have used marajuanna twice. Yes, it does have side effects, but to be honest, I found them much less harsh than amitriptyline, and I slep great on it. Nobody here is looking for perfection, just improvement.
Linkadge
poster:linkadge
thread:991238
URL: http://www.dr-bob.org/babble/20110714/msgs/991341.html